Systems biology involves large scale exploratory data acquisition and visualization; data integration and the formulation of quantitative models; and the testing of these models and the hypotheses they generate with further experimentation. I will present examples in cell biology, and infectious diseases where modeling data resulting from this approach has led to fundamental insights into transcriptional network dynamics, peroxisome biogenesis, malaria and innate immune responses to infections.
Dr. John Aitchison is co-director of the Center for Global Infectious Disease Research at the Seattle Children’s Research Institute and a Professor in the Department of Pediatrics at UW. His research brings systems biology to infectious disease research and uses the challenges of infectious diseases to develop systems biology. Dr. Aitchison also holds affiliate appointments at the Institute for Systems Biology, University of Washington, University of Alberta, and University of British Columbia and Rockefeller University. He is a member of the Molecular and Cellular Biology and Biomolecular Structural Design Graduate Programs at the University of Washington.
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